This test is specific for the mutation known to cause Factor VII deficiency in Airedale, Alaskan Klee Kai, Beagle, Giant Schnauzer, and Scottish Deerhounds.
Factor VII is a clotting factor synthesized in the liver that is necessary to initiate blood clotting. Factor VII deficiency can be mild to moderate and is inherited as an autosomal recessive. Both males and females can be affected if they carry 2 copies of the defective gene. Carriers only one copy are not affected.
Results reported as:
N/N Normal – no copies of the Factor VII deficiency mutation are present
N/FVII Carrier – 1 copy of the Factor VII deficiency mutation is present. If carriers are bred together, 25% of offspring are expected to be affected.
Callan MB, Aljamali MN, Margaritis P, Griot-Wenk ME, Pollak ES, Werner P, Giger U and High KA (2006). A novel missense mutation responsible for factor VII deficiency in research Beagle colonies. Journal of Thrombosis and Haemostasis, 4:2616–2622.